High pressure microfluidic homogenizer - a new generation of high pressure homogenization technology to reduce the molecular weight of polysaccharides
2022-08-10
Polysaccharides are polysaccharide macromolecular carbohydrates composed of at least 10 monosaccharides with sugar chains bound by glycosidic bonds. Polysaccharides composed of the same monosaccharide are called homopolysaccharides, such as starch, cellulose and glycogen; polysaccharides composed of different monosaccharides are called heteropolysaccharides, such as gum arabic, which is composed of pentose and galactose. Polysaccharide is not a pure chemical substance, but a mixture of substances with different degrees of polymerization. Polysaccharides are generally insoluble in water, have no sweet taste, cannot form crystals, and have no reducibility and mutarotation. Polysaccharides are also glycosides, so they can be hydrolyzed. During the hydrolysis process, a series of intermediate products are often produced, and finally monosaccharides are completely hydrolyzed. One of the most beneficial aspects of polysaccharides for pharmaceutical use is that they are biocompatible and biodegradable, and can be broken down naturally by the body, while also possessing many properties that make their hydrophilic structure more likely to target tumors , and its hydrophobic group provides a good carrier for insoluble drugs. Polysaccharides can also be used to form conjugate vaccines. However, the starting molecular weight of most polysaccharides is too large to take advantage of these great drug carrier properties.